The SELECT cardiovascular outcomes trial (Lincoff et al., 2023, New England Journal of Medicine) enrolled 17,604 adults with obesity and established cardiovascular disease no diabetes, and demonstrated a 20% reduction in major adverse cardiovascular events (MACE) with 2.4mg semaglutide versus placebo
What we check before starting a GLP-1, regardless of cancer history: Personal and family history of medullary thyroid cancer or MEN 2 Personal history of pancreatitis or significant gallbladder disease Current eating disorder symptoms Other medications that may interact Pregnancy plans, since these medications are not for use during pregnancy Whether age- and risk-appropriate cancer screening (mammogram, colonoscopy, cervical) is up to date Three things we try not to assume: That a strong family history of breast cancer changes someone's GLP-1 candidacy by itself
Key benefits of CJC-1295 include: Stimulating GH and IGF-1 production Enhancing muscle recovery and growth Supporting deep, restorative sleep Improving fat metabolism and body composition Promoting skin elasticity and collagen production Ipamorelin: The Clean Growth Hormone Secretagogue Ipamorelin is a ghrelin mimetic , meaning it binds to ghrelin receptors in the hypothalamus and stimulates growth hormone release without raising cortisol , prolactin , or desensitizing receptors
Most healthcare providers recommend waiting 24 weeks after weaning to ensure hormonal and metabolic stabilization before initiating GLP-1 therapy
