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There are different ways liver diseases impact your hormones, including some of the most common: Increasing production of androgens by your adrenal glands Affecting the way androgens and estrogen interact Reducing your bodys ability to clear adrenal androgens by the liver Increasing blood levels of sex hormone-binding globulin (SHBG) Alcohol-related liver disease also elevates your risk of developing gynecomastia since the phytoestrogens and ethanol, which inhibits testosterone, disrupt your estrogen-testosterone balance

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