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Updated Phase 3 Data from 2025: The Numbers Got Even Better In December 2025, Eli Lilly released topline results from the TRIUMPH-4 Phase 3 trial, and the numbers exceeded even the most optimistic projections from Wall Street analysts

Injection site reactions occur in roughly 1.4% to 2.4% of patients using subcutaneous semaglutide, according to clinical trial data

Exendin-4 also rescues the cytokine-induced reduction of electron transport chain proteins of mitochondria and leads to decrease oxidative stress and alleviate apoptosis 11