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D-carnitine supplements should be avoided as they interfere with the natural form of L-carnitine and may produce undesirable side effects

Insulin release and action have to precisely meet the metabolic demand

Extrinsic aging is predominantly influenced by sun exposure (photoaging), although smoking and pollution also play a role.1 Intrinsic and extrinsic aging overlap in clinical practice.1 Demand for strategies to mitigate the signs of skin aging is high.2 Recent studies suggest that regular exercise, apart from improving quality of life and reducing the risk of mortality and chronic disease,2 might also reduce the thickness of the stratum corneum and improve dermal thickness and collagen content.3 Diet is also important, with a number of studies highlighting its role in the prevention of aging