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1 Muscle mass often decreases, lowering resting metabolic rate

[16] These medications work through multiple complementary mechanisms: they enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release from alpha cells, slow gastric emptying to reduce postprandial glucose excursions, and act on central nervous system pathways to promote satiety and reduce appetite

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More than 70% of Americans feel it has failed them