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Neurogenic claudication is a cluster of symptoms such as cramping, burning, and tingling that may start in the lower back and move to the buttocks, groin, and anterior thigh and radiate down the posterior part of the legs, causing a perceived loss of balance

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Receptor abnormalities (e.g., reduced 5-HT receptors [28], presynaptic 2-adrenoceptor hypersensitivity [29]) also contribute and offer treatment targets [30] (Figure 2)