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For the longitudinal clinical study, ASL perfusion MR images were obtained using a pCASL single-shot echo-planar imaging sequence with the following parameters: TE of 11 ms, TR of 4000 ms, FOV of 220 220 mm, voxel size of 2.75 2.75 mm, slice thickness of 6 mm, 18 slices, a labeling duration of 1650 ms, a post labeling delay of 1600 ms, and 40 control-label pairs

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As control, knock-outs of our predicted targets were performed in healthy melanocyte sample-specific models (IN-HOUSE-CONTROL) to assess the impact on ATP maintenance (Fig

In addition to the acquirement of drug-resistant mutation, the development of cancer stem cells also causes CML persistence and relapse from TKI therapy 12,13,14