is semaglutide safe for pregnancy & Pregnancy: Safety, Evidence & Medical Considerat... – PlexusDx Ozempic and Pregnancy: Can You

There is evidence on DIBP being a subchronic toxicant

The human skin is a complete steroidogenic organ, as intracrine estrogen biosynthesis occurs either from precursors of adrenal origin (dehydroepiandrosterone sulfate [DHEA-S] and DHEA) or through the conversion of cholesterol to pregnenolone and its subsequent transformation to biologically active estrogen in skin cells (Labrie et al., 2000

Thus, integration of both hormones into a single molecule may not only maximize the metabolic efficacy of the individual signals, but allow also specific delivery of estrogen into GLP1 receptor-expressing cells, avoiding potential undesired effects of estrogen on reproductive tissues, as shown also in our studies

Mixing methods inappropriately Applying topical doses to injectable protocols or vice versa makes no sense given bioavailability differences