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The increase in central neural activity is believed to be a consequence of an alteration in the normal balance between excitation and inhibition in nerve transmission, potentially due to a diminution of GABAergic inhibition 50,51,52

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In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis ( 102 prevented erastin-induced ferroptosis evidently in a dose-dependent manner ( Figure 8A ), even when the concentration of erastin reached to 100 M ( Figure 8B )