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Medical Pharmacology Chapter 2: General Principles: Pharmacokinetics Cytochrome P450 Enzyme Induction: Following repeated administration, some drugs increase the amount of P450 enzyme usually by: Increase enzyme synthesis rate (induction) Reduced enzyme degradation rate Cytochrome P450 enzyme inhibition: Certain drugs, by binding to the cytochrome component, act to competitively inhibit metabolism

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doi: 10.1530/eje.0.1440251 104 MazziottiGGiustinaA

ARA 290 at concentrations exceeding ~1 ng/mL activates the IRR, which functions as a molecular switch to provide long-lasting effects, similar to other effector molecules in the immune response