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Food and Drug Administration approved semaglutide, under the brand name Wegovy, for chronic weight management in obese and overweight adults

Since weight loss medications work systemically through receptor activation rather than requiring gallbladder function, the absence of this organ does not fundamentally impair their therapeutic mechanism

This is particularly relevant given the increasing combined use of these effective drug classes.1011 Biological mechanisms The associations observed with the GLP-1 receptor agonist-SGLT-2 inhibitor combination in this study can be attributed to an additive effect resulting from their different yet complementary mechanisms of action