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The cumulative effect is a meaningful increase in irritation risk: over-exfoliation, a compromised skin barrier, redness, flaking, and sensitivity

Synthetic forms of vitamin K, particularly menadione (vitamin K3) , have been associated with adverse effects including haemolytic anaemia and liver toxicity in animal studies

In addition, the availability of novel cellular systems, such as cybrids or induced pluripotent stem cells, offers the chance to exploit the advantages of an in vitro investigation, although mirroring more closely the cell population being affected (Wang et al