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When activated, the Nrf2 pathway upregulates the expression of a wide range of genes that help to protect cells against various stressors such as reactive oxygen species (ROS), electrophiles, and xenobiotics

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According to the 2021 review, Exenatide XR had the lowest rate of gastrointestinal side effects, while semaglutide injections were associated with the highest rate of these side effects

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