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143 A large body of evidence demonstrates that oxLDL is closely associated with coronary and peripheral artery disease, hypertension, ischemic stroke and acute coronary syndrome, as well as cardiovascular risk factors including diabetes, obesity, chronic inflammation, and metabolic syndrome

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In addition to inhibiting NF-kB signaling, riboflavin can also inhibit critical components of the non-canonical inflammasomes, such as caspase-1 activity 47 , either via the AIM2 cytosolic innate immune receptor, which recognizes double-stranded DNA (dsDNA) released during cellular perturbation, or via the Nod-like receptor NLRC4, which recognizes bacterial ligands such as flagellin and the type three secretion system (T3SS) 47