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San Diego, CA: Academic Press

Step 3: Inject the water gently down the side of the vial, allowing it to run down the glass and gradually dissolve the powder

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Providing that it may be induced rapidly, and then persisting for hour and day periods, this damaging effect is obviously part and parcel of general NSAIDs-toxicity, including gastric and small intestine ulcers, hepatotoxicity and encephalopathy (3, 8-14)