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Incretin analogues are an increasingly important class of drugs that provide substantial health benefits for people with obesity, with adverse effects limited primarily to gastrointestinal disturbances

Their activation involves G protein (Gs), leading to increased insulin secretion in beta cells via cyclic adenosine monophosphate (cAMP) production, but they also activate the beta-arrestin pathway, which impedes G-protein signaling

[2] Other conditions giving rise to malabsorption include surgical removal of the stomach, chronic inflammation of the pancreas, intestinal parasites, certain medications such as long-term use of proton pump inhibitors, H2-receptor blockers, and metformin, and some genetic disorders