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Concurrently, ER stress can upregulate TH expression, leading to overactivation of dopaminergic neurons and the generation of neurotoxic metabolites, thereby exacerbating apoptosis (1417)

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Recently this question arose following the finding that Foreo (teriparatide), a truncated analog of naturally-occurring parathyroid hormone (PTH) causes osteosarcoma in animals, and possibly in humans as well