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, In 1997, the World Health Organization declared obesity a global epidemic and since then, the prevalence of obesity has continued to rise

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The molecule itself is fragile compared to small-molecule medications

[3] The mechanism driving muscle loss during prolonged caloric restriction involves increased muscle proteolysis rather than suppressed protein synthesis, [4] meaning the body actively breaks down existing muscle tissue to meet energy demands, and this process accelerates in hormone-deficient states