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However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers

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This also explains why these compounds are often compared with, rather than pitted against, traditional nootropic supplements and smart drugs

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Oncotarget 8 , 2662526636 (2017)

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