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A 2023 systematic review confirmed this trend, finding that blood glutathione levels consistently decline across the adult lifespan, while oxidative stress simultaneously increases

The Role of Alcohol Metabolism in the Pathology of Alcohol Hangover [online]

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Electrons are then transferred from the oxidoreductase flavoenzyme to the appropriate electron carrier, either oxidized thioredoxin (Trx-S2) or glutathione disulfide (GSSG) converting them to reduced thioredoxin (Trx-[SH]2) or glutathione (GSH), respectively