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As a link between intestinal endocrine cells and pancreatic -cells, GLP-1 can regulate insulin secretion in a glucose-dependent manner, and it is jointly responsible for approximately 50% of nutritionally induced insulin secretion with GIP ( in vivo experiments revealing a temporal difference in GLP-1 secretion and demonstrating that early GLP-1 and GIP release was more pronounced in the morning than in the afternoon ( in vivo GLP-1 test in response to OGTT in mice ( Furthermore, the intestinal flora regulation of GLP-1 secretion rhythm should not be neglected

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Jalleh RJ, Plummer MP, Marathe CS, Umapathysivam MM, Quast DR, Rayner CK et al (2024) Clinical consequences of delayed gastric emptying with GLP-1 receptor agonists and tirzepatide