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The feedback mechanisms associated with leptin resistance and hyperinsulinemia intensify hormonal imbalances, obstructing follicle maturation and oocyte development [94]

Despite a reduction in potency relative to these standards, the observed GIPR activity suggests its potential as a molecular starting point for the rational design of triple-acting ligands (GLP-1R/GIPR/DOR)

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These two peptides can potentially work together to stimulate the pituitary gland to release natural growth hormone in a controlled and balanced manner