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The cytoplasmic tail of the severe acute respiratory syndrome coronavirus spike protein contains a novel endoplasmic reticulum retrieval signal that binds COPI and promotes interaction with membrane protein

Researchers are increasingly interested in RETA because of its unique research profile and the growing number of studies exploring its interaction with biological signaling pathways

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Therefore, we emphasize a risk-factor-based escalation model, where comorbidities, treatment response, and functional limitations guide progression through treatment steps