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Remarkably, 71% of ApoJ-positive amyloid plaques were surrounded by dystrophic neurites marked by phosphorylated tau protein, while 64% of tau-positive neurofibrillary plaques showed ApoJ immunoreactivity

Lombardo F, Lunghi R, Pallotti F, Palumbo A, Senofonte G, Cefaloni AC, et al

There are currently no effective treatments for ALS due to the complexity and heterogeneity of factors involved in motor neuron degeneration

In rodent and primate metabolic models, amylin analogue administration has been shown to attenuate glucagon-driven hepatic glucose output and reduce postprandial glycemic excursions, independently of insulin secretion (Verchere et al., Proceedings of the National Academy of Sciences, 1996