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There have been select cases of B6-related anemia in which taking the inactive pyridoxine hydrochloride (HCl) form of the vitamin didnt help

When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

This means that it's composed of three amino acids

Choose injection site: Abdomen (at least 2 inches from navel), outer thigh, upper outer arm, or buttocksareas with subcutaneous fat layer [7]