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Jastreboff, L

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KPV, a tripeptide composed of lysine, proline, and valine, exhibits potent anti-inflammatory properties, although its mechanisms of action have remained elusive

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They showed that lactylation of the DNA damage response factor NBS1 enhances homologous recombination repair and promotes resistance to platinum-based chemotherapy, whereas pharmacologic inhibition of NBS1 lactylation using stiripentol, an antiepileptic drug already approved for Dravet syndrome, restored chemosensitivity in multiple tumor models

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