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In addition, the characterized LASSS treatment did not stimulate autolysis of HGF as monitored by SDS-PAGE for degradation of 60-kDa -chain and 90-kDa proform of recombinant HGF incubated with LASSS (at 1:8000) at 25 for 2 h (see supplementary Figure 1b), providing another important basis for the availability of LASSS-HGF

doi: 10.1007/s10637-013-0047-4 244 LiBLiXNiZZhangYZengYYanXet al

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Most studies report: No observable toxicity No organ damage No carcinogenic findings in short-term studies However: Long-term human clinical data is limited Most evidence remains preclinical Reference: Sikiric et al., 2018 safety review Summary: BPC-157 Peptide BPC 157 peptides are among the most studied regenerative peptides in experimental research