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This has not been confirmed in humans, but the pill is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma
Notably, studies in mice demonstrate that GLP-1R agonists specifically localize to and require arginine vasopressin neurons in the PVN to exert their hypophagic and weight-reducing effects, a process that is amplified by GIPR co-activation [81]
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