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Hepatocyte-specific SIRT1 knockout mice exhibit impaired glucose tolerance, decreased insulin sensitivity, and elevated HOMA-IR values, supporting a protective role of SIRT1 in hepatic glucose homeostasis

These symptoms typically occur during dose escalation and often improve with continued therapy

Toxicol Appl Pharmacol 128:199206 Lenkowski JR, Raymond PA (2014) Mller glia: stem cells for generation and regeneration of retinal neurons in teleost fish