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In general, mycotoxins affect the physical (intestinal cell proliferation, cell viability, cell apoptosis), chemical (mucins, AMPs), immunological, and microbial barriers of the gut, as reported by Gao et al

Another emerging idea is that a general 'anti-fibroblast strategy' may not suffice, and a better definition of fibroblast heterogeneity together with the specialised functions of the different subsets is needed to fine-tune potential fibroblast-based therapeutic approaches

These effects are exacerbated by low folate intake

16 Joint & Musculoskeletal Pain Overweight and obesity have a profound impact on overall physical function, musculoskeletal pain and both the development and progression of osteoarthritis