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P=.03).13 Another found no significant differences,14 while the third, which analyzed a group of 302 patients admitted for acute coronary syndrome, found greater efficacy in the group that received varenicline compared to the control group (47.3 vs 32.5%, P=.012).15 It is also important to point out that the use of varenicline in hospitalized patients, some of whom have chronic diseases, is as safe as placebo, and nausea was the only event that appeared more frequently in the active treatment group (16.3 vs 1.5%).14,16 Even in the group of subjects admitted for acute coronary syndrome, varenicline was shown to be as safe as placebo