Among these, glucagon-like peptide-1 receptor agonists (GLP1RAs) have attracted particular attention for their profound effects on body weight, glycemic control, and cardiovascular outcomes [4,5] , which extend beyond metabolic effects [4] , alongside emerging evidence of liver-specific benefits [5,6]
Serum granulysin has a sensitivity of 80% and specificity of 95.7% for early diagnosis of SJS/TEN in patients with nonspecific drug rash, and a rapid immunochromatographic test strip for granulysin has been developed, though is not yet widely available [76]
Maintaining improvements long-term requires either continued use or transition to lifestyle interventions that sustain AMPK activation (resistance training, caloric cycling)
Each pen is preloaded and designed to administer small, controlled doses consistently