glutathione and nac supplements Carlson N-Acetyl Cysteine, 500 mg - 60 Capsules Liposomal Vitamin C+ Platinum -

The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, or in writing the manuscript

Inducible NOS (NOS2) and neuronal NOS (NOS1) are involved in neurotoxicity, leading to excitotoxicity cascades, inflammation, apoptosis, and deterioration to the primary brain injury through the release of free radicals and production of nitrates, which directly damage mitochondrial enzymes and genetic material (Sims and Anderson, 2002

Upregulated expression of these two transporters can significantly accelerate the efflux of platinum agents from cells and reduce intracellular platinum accumulation, which not only impairs anti-tumor efficacy and mediates chemotherapy resistance, but also affects cumulative toxicity by altering the tissue distribution profile of the agents

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