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This animal model also exhibit a dysregulation of Nrf2-dependent antioxidant responses in the vasculature, which promotes the development of marked endothelial dysfunction and endothelial apoptosis in the presence of increased oxidative stress[281], mimicking the aging phenotype

The FDA cited three concerns: potential immunogenicity (the peptide could trigger immune reactions), manufacturing impurity risks (synthetic peptides can contain truncated sequences and other contaminants), and a lack of human safety data sufficient to evaluate risk

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