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J Biol Chem 295:20182033

If tirzepatide is not effective, mazdutide may work better due to its different secondary mechanism, and vice versa

Regular follow-up appointments during Wegovy treatment provide opportunity to discuss any concerns about digestive function and ensure that weight management proceeds safely and effectively

In contrast to the enhancement of spontaneous excitatory postsynaptic transmission ( in vitro patch-clamp recordings showed that exendin-4 selectively inhibits the miniature excitatory postsynaptic currents (mEPSCs) within the dopaminergic VTA-to-NAc projection neurons (Wang et al., 2015