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doi: 10.1053/j.gastro.2016.01.032 48

This effect may be explained by at least three potential mechanisms: (1) enhanced DUB activity reverses stress-induced ubiquitylation on proteasome subunits such as RPN10 or RPN13, which otherwise promotes dissociation of the 19S regulatory particle from the 26S complex

A 2020 systematic review and meta-analysis published in Clinical Nutrition ESPEN (Asbaghi et al., 12 randomized controlled trials) reported oral berberine supplementation produced a statistically significant weighted mean reduction of 2.07kg in body weight, 0.47 kg/m in BMI, and 1.08cm in waist circumference versus placebo