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Calcium affects oxidative phosphorylation, and calcium buildup within mitochondria can cause the electrochemical proton gradient to collapse, resulting in bioenergetic failure and necrotic cell death [140]

The GshF activities were similar for all three strains when the IPTG concentration was 0.5 mM for ZJ1234 and ZJ12345 and 0.05 mM for ZJ000

Consequently, since the 1960s, the drug has been approved as an inhalation therapy for patients diagnosed with CF, but its effects on improving lung function or reducing pulmonary exacerbations have not yet been fully established [121,122]

Abegg D, Tomanik M, Qiu N, Pechalrieu D, Shuster A, Commare B, et al