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The landmark STEP trials showed that patients lost an average of 15-20% of their body weight over 68 weeks when combining semaglutide with lifestyle modifications

This study not only found that the cGAS-STING-ferroptosis pathway was a druggable target in joints, but also pioneered a new flexible delivery platform that resolved the key limitation of low local drug concentrations in joints after systemic administration, and offered a cartilage-protecting perspective for RA

What GLP-1s Are Doing Beyond Weight-Loss One of the biggest myths about GLP-1 medications is that theyre cosmetic or optional

2022;16(11) doi: 10.1016/j.dsx.2022.102656