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For instance, studies demonstrate distinct gene expression patterns and immune cell infiltrates between eutopic and ectopic tissues, and across lesion locations, suggesting variable responsiveness to immunomodulatory or microbiome-targeted therapies ( Future therapeutic frameworks should thus integrate phenotypic, molecular, and patient-specific factors to guide individualized treatment

In tumor tissues, aerobic glycolysis with abnormal release of adenosine triphosphate (ATP) and lactate, which is known as the Warburg effect, fulfills the requirement of rapid tumor growth [115,122,123]

Revised: 11/2024 v4 This Instructions for Use has been approved by the U.S

Larsen, P