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However, its risk-benefit profile is still unclear at this stage, which is why it is not approved by the FDA

Inhibition of GLS with BPTES or genetic silencing of GLS/GLS2 genes increases radiation sensitivity in lung and prostate cancer cell lines

VacA exerts multiple effects on epithelial cells resulting in the induction of vacuole formation in the gastric epithelial cellular membrane, cellular damage, an increase of intracellular permeability and the modulation of apoptosis rather than release of pro-inflammatory cytokines (see Fig