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In ageing yeast, spermidine treatment triggered the deacetylation of the histone, H3, through the inhibition of histone acetyltransferases (HAT EC 2.3.1.48), suppressing oxidative stress and inducing apoptosis [115]

In OC development, the involvement of -catenin in the Wnt/-catenin signaling pathway has been observed in stem cell proliferation and differentiation, as well as in drug resistance in OCSCs