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A recent longitudinal case series study with 60 subjects found that co-occurring psychiatric disorders were strongly linked to negative treatment outcomes for people with psychophysiological insomnia, and people with strong social support and cognitive coping skills were most successful in treatment

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Obesity is a network disease involving appetite regulation, reward signaling, gut-brain hormones, and energy expenditure pathways

457 Activation of N-methyl-D-aspartate (NMDA) receptors amplifies and prolongs spinal dorsal horn neuron responses, further contributing to pain perception