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10.1007/s10439-024-03459-3 46

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The shift increases alcohol breakdown but also generates large amounts of reactive oxygen species (ROS), contributing to tissue damage during chronic drinking

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcription factor upregulating the antioxidant response element (ARE)-mediated expression of antioxidant and detoxifying enzymes, and the Nrf2-antioxidant pathway is critical in host defense against acute lung injury (ALI) 24