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Sarcopenia has also been associated with negative outcomes in patients with end-stage kidney disease or on dialysis [118,119,120,121]
Investigation of the mechanisms underlying the beneficial metabolic effects of multi-agonist therapies, conducted in PWA mice, as a genuine model for the metabolic alterations of PCOS 36 , revealed a predominant action in terms of suppression of food intake, with negligible effects in terms of energy expenditure, thermogenic function or locomotor activity
While this study population was specific, the magnitude of weight loss aligns with and extends the Phase 2 findings, suggesting that the 24% range is reproducible across populations at the highest dose
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