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A relevant issue that remains controversial is whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on the pancreas or other extrahepatic tissues, or direct, i.e., through activating GLP-1R on hepatocytes

This risk has only been seen in animal studies, not in humans, but the medications still arent recommended if you or a family member has a history of this cancer or a condition called MEN 2