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Paracrine regulation of growth hormone gene expression by gonadotrophin release in grass carp pituitary cells: Functional implications, molecular mechanisms and signal transduction

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A pooled analysis of these two randomised-controlled trials demonstrated a placebo-adjusted reduction in OFF-time of 1 h from baseline to week 12 [143], and an open-label extension showed persistent improvement of MDS-UPDR part IV motor fluctuation subscore after 100 weeks of treatment [144, 145]