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The habenula has notably high levels of MOR (medial habenula) [44] and also expresses KOR (lateral habenula) [45], is implicated in aversive states [46] including NPW [20], and modulates DA release [47, 48]

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In 2021, the numbers of AAF were 33% from SERMs (tamoxifen and clomiphene) and 15% from AIs (anastrozole, letrozole, adrostatrienedione, armistane, and 2-androstenone) (World Anti-Doping Agency, 2024a)