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Concomitantly, the swing of R283 6.55 leads to the rotameric switches of F279 6.51 and W276 6.48 , a residue in conserved micro-switch

In a series of further experiments, we identified that Efavirenz dysregulated ER stress and autophagy by blocking the activity of the Beclin-1/Atg14/PI3KIII complex in regard to synthesis of phosphatidylinositol 3-phosphate (PI3P), a process which is linked to the formation of autophagosomes

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