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These oligomeric complexes cause a loss of transmembrane potential, prompting the release of Cyt C from the mitochondria into the cytoplasm

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In the case of Ex4-D-Ala, if the agonist can partially disengage from the TM core but retain other receptor contacts, then the receptor could release the activated G protein and be ready to activate a newly recruited G protein

They are more likely to have worse outcomes post-cardiovascular events