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The evidence is unclear or shows little to no benefit from using B12 supplementation, but more research is needed in these areas

This process is morphologically marked by small mitochondria with condensed membrane densities, and biochemically by iron overload and GSH depletion, leading to loss of antioxidant defense and irreversible oxidative damage ( 3.2 Key molecular drivers of ferroptosis Iron Overload: Excess intracellular ferrous iron (Fe 2+ ) catalyzes the Fenton reaction, producing hydroxyl radicals (OH) that initiate lipid peroxidation cascades

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[DOI] [PubMed] [Google Scholar] 62.Perovic D., Kolenc D., Bilic V., Somun N., Drmic D., Elabjer E., Buljat G., Seiwerth S., Sikiric P